Related Experiment Video
Updated: Dec 21, 2025
Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury
Published on: March 21, 2021
Allergy and Lung Injury Among Rescue Workers Exposed to the World Trade Center Disaster Assessed 17 Years After
Dennis L Caruana1, Po Hsuan Huang, Jonathan C Li
1Yale School of Medicine, New Haven, Connecticut (Mr Caruana); California University of Science and Medicine School of Medicine, San Bernardino, California (Mr Huang); Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania (Dr Li); Internal Medicine/Pediatrics Residency Program, Christiana Care Health System, Wilmington, Delaware (Dr Li); New York State Psychiatric Institute, Columbia University (Dr Cheslack-Postava); International Center for Excellence in Deployment Health and Medical Geosciences, Northwell Health, New Hyde Park (Dr Szema); Department of Occupational Medicine, Epidemiology, and Prevention, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead (Dr Szema); Division of Pulmonary and Critical Care (Dr Szema); Division of Allergy/Immunology (Dr Szema); Department of Medicine, Northwell Health, Great Neck; Department of Technology and Society, College of Engineering and Applied Sciences, Stony Brook University, Stony Brook (Dr Szema); Three Village Allergy & Asthma, PLLC, South Setauket (Dr Szema), New York.
Objective:
Investigate the following in rescue and cleanup workers exposed to the World Trade Center (WTC) disaster 17 years post-fallout: (1) allergic hypersensitivity; (2) spirometry; (3) impulse oscillometry; and (4) the reversibility of airway hyperresponsiveness and distal airways narrowing pre- and post-bronchodilator.
Methods:
In subjects (n = 54) referred to our clinic from the WTC Health Program for management of allergy-immunology services, environmental allergy testing, impulse oscillometry (IOS), and spirometry results were retrospectively reviewed to determine the long-term impact of exposure to the WTC fallout.
Results:
Rescue and cleanup workers exposed to the WTC fallout had a high incidence of allergic hypersensitivity and had evidence of permanent small airways dysfunction characterized by distal airways narrowing and airway hyperresponsiveness.
Conclusion:
Following exposure to the WTC disaster, the patients in our cohort developed allergic hypersensitivity and severe lung injury with only partial reversibility.
More Related Videos
10:10Assessment of the Acute Inhalation Toxicity of Airborne Particles by Exposing Cultivated Human Lung Cells at the Air-Liquid Interface
Published on: February 23, 2020
12:04Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices
Published on: May 9, 2018
Related Concept Videos
02:06Allergic Reactions
01:36Types of Toxins
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
01:17Pulmonary Cycle: Exhalation
01:29Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
01:29Asthma-I: Introduction