Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

394
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
394
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

1.7K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.7K
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

383
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
383
Schizophrenia01:17

Schizophrenia

610
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
610
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.0K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.0K
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

3.2K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

BDNF-DT and BDNF-AS-DT: novel genes in the BDNF locus.

Molecular psychiatry·2026
Same author

Co-expression-based models improve eQTL predictions for transcriptome-wide association studies and highlight new schizophrenia-associated genes.

Nature genetics·2026
Same author

Trisomy 21 Drives ADARB1 Overexpression and Premature RNA Recoding in the Developing Fetal Brain.

Nature communications·2026
Same author

SETD1A regulates psychiatric gene networks involved in genomic stability and synaptic function in rare and sporadic schizophrenia.

Nature communications·2025
Same author

<i>APOE</i> E4 Alzheimer's Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex.

bioRxiv : the preprint server for biology·2025
Same author

Impact of Alzheimer's disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Dec 21, 2025

Modeling Human Cerebellar Development In Vitro in 2D Structure
06:14

Modeling Human Cerebellar Development In Vitro in 2D Structure

Published on: September 16, 2022

2.0K

Cortical cellular diversity and development in schizophrenia.

Amanda J Price1,2, Andrew E Jaffe1,2,3,4,5,6, Daniel R Weinberger7,8,9,10,11

  • 1Lieber Institute for Brain Development, Baltimore, MD, USA.

Molecular Psychiatry
|May 15, 2020
PubMed
Summary
This summary is machine-generated.

Schizophrenia may stem from early brain development disruptions affecting cell maturation. Studying gene regulation across diverse brain cells offers insights into this complex psychiatric disorder.

More Related Videos

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells
08:04

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells

Published on: November 19, 2020

6.9K
Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM
09:25

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM

Published on: May 8, 2020

11.2K

Related Experiment Videos

Last Updated: Dec 21, 2025

Modeling Human Cerebellar Development In Vitro in 2D Structure
06:14

Modeling Human Cerebellar Development In Vitro in 2D Structure

Published on: September 16, 2022

2.0K
Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells
08:04

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells

Published on: November 19, 2020

6.9K
Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM
09:25

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM

Published on: May 8, 2020

11.2K

Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Biology

Background:

  • Schizophrenia etiology remains unclear, but early developmental disruptions impacting brain maturation are increasingly implicated.
  • Atypical brain development in schizophrenia involves complex interactions between various cell types with distinct developmental paths.

Purpose of the Study:

  • To review human brain cellular composition and development.
  • To explore genomic regulation (transcriptome and epigenome) in cell identity and development.
  • To summarize dysregulation of genomic regulation in specific cell types in schizophrenia.

Main Methods:

  • Survey of existing literature on human brain development and cellular composition.
  • Analysis of genomic regulation mechanisms (transcriptome, epigenome).
  • Review of studies investigating cell type-specific genomic dysregulation in schizophrenia.

Main Results:

  • Early developmental perturbations significantly alter brain maturation trajectories in schizophrenia.
  • Transcriptome and epigenome alterations reflect genetic and environmental influences on cellular development.
  • Specific cell types exhibit dysregulated genomic regulation in schizophrenia.

Conclusions:

  • Understanding schizophrenia requires examining "omic" changes across diverse brain cells during development.
  • Cell type-specific functional genomic studies in postmortem brain are crucial but face technical challenges.
  • Further research into developmental trajectories and genomic regulation is vital for unraveling schizophrenia etiology.