Diffuse large B-cell lymphoma presenting with cavitary lung disease

Diffuse large B-cell lymphoma (DLBCL) with cavitary lung disease is rare and is often difficult to differentiate from primary lung cancer, granulomatous disease, or an infectious disease based on imaging findings alone. We herein report a case in which a patient with DLBCL presented with cavitary lung disease and splenic mass, which was diagnosed by transbronchial biopsy. DLBCL should be considered as a differential diagnosis in patients with cavitary lung diseases who have rare metastatic lesions for primary lung cancer, such as intra-abdominal lymph nodes or spleen.