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Hormonal Biophysiology of the Uterus.

Advances in experimental medicine and biology·2020
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Hormone Therapy Effects on the Uterus.

Liane Deligdisch-Schor1,2

  • 1Professor Emeritus, Department of Pathology, The Icahn School of Medicine at Mount Sinai, New York, NY, USA. lianedelig@gmail.com.

Advances in Experimental Medicine and Biology
|May 15, 2020
PubMed
Summary

Hormone therapy significantly impacts uterine tissue, causing complex histological changes. Accurate interpretation of endometrial biopsies is crucial for managing gynecological pathology in women undergoing hormone treatments.

Keywords:
ContraceptivesEndometrial cancerEndometriumEstrogensHormone receptorsHormone therapyMenopauseProgesteroneSteroid sex hormonesUterus

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Area of Science:

  • Gynecological Pathology
  • Endocrinology
  • Reproductive Medicine

Background:

  • The endometrium is highly responsive to steroid sex hormones, influencing reproductive functions.
  • Hormone therapy is widely used globally for contraception, stimulation, replacement, and antitumoral treatments.
  • Millions of women utilize hormone therapy, making its effects on uterine tissue a significant clinical concern.

Purpose of the Study:

  • To address common challenges in interpreting the histological changes in uterine tissue due to hormone therapy.
  • To provide guidance for gynecological pathology interpretation in the context of diverse hormonal treatments.
  • To clarify the complex histologic alterations in the endometrium caused by various hormone therapies.

Main Methods:

  • Review of gynecological pathology literature concerning hormone therapy.
  • Analysis of histological changes in endometrial biopsies from women on hormone therapy.
  • Discussion of evolving hormonal pharmaceutical products, regimens, and therapeutic concepts.

Main Results:

  • Hormone therapy induces prompt and versatile structural and functional modifications in the uterus, particularly the endometrium.
  • Histological interpretation of endometrial biopsies from women on hormone therapy is often complex and confusing.
  • Constantly changing hormonal products, dosages, and therapeutic strategies present diagnostic challenges.

Conclusions:

  • Accurate interpretation of hormone therapy's effects on uterine tissue is essential for effective patient management.
  • Understanding the histological complexity is vital for both medical prescribers and users of hormone therapy.
  • This work aims to clarify common issues in gynecological pathology related to hormone therapy's impact on the uterus.