Related Experiment Video

Updated: Dec 21, 2025

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
12:26

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

19.2K

The role of CDK6 in cancer

Sofie Nebenfuehr1, Karoline Kollmann1, Veronika Sexl1

  • 1Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Vienna, Austria.

International Journal of Cancer
|May 15, 2020
PubMed

Insights

Cyclin-dependent kinase 6 (CDK6) and cyclin-dependent kinase 4 (CDK4) are key in cancers. Novel therapies targeting CDK6's non-kinase functions may improve cancer treatment outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • Cyclin-dependent kinase 6 (CDK6) and cyclin-dependent kinase 4 (CDK4) complexes are frequently dysregulated in various cancers, including hematologic malignancies, breast cancer, and melanoma.
  • Enhanced kinase activity of CDK4/6 complexes contributes to cancer development, making them attractive therapeutic targets.

Purpose of the Study:

  • To review the latest findings on the role of CDK6 in cancer development.
  • To discuss novel therapeutic strategies that selectively inhibit the kinase-independent functions of CDK6 as a transcriptional regulator.

Main Methods:

  • Literature review of recent studies on CDK6 in cancer.
  • Analysis of therapeutic approaches targeting CDK6's transcriptional regulatory roles.

Main Results:

  • Dual CDK4/6 inhibitors have shown success in breast cancer and other malignancies.
  • CDK6 possesses kinase-independent functions crucial for cancer progression.
  • Targeting these unique functions offers a promising avenue for novel cancer therapies.

Conclusions:

  • While dual CDK4/6 inhibitors are effective, there is a significant need for therapies that specifically target CDK6's non-kinase activities.
  • Selective inhibition of CDK6's role as a transcriptional regulator represents a novel strategy to improve cancer treatment efficacy.
Keywords:
CDK4CDK4/6 inhibitorsCDK6cancer

More Related Videos

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

28.2K
Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer08:34

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

10.6K

Related Concept Videos

Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
5.5K
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
6.2K
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
6.4K
Positive Regulator Molecules01:45

Positive Regulator Molecules

To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
133.1K
S-Cdk Initiates DNA Replication02:38

S-Cdk Initiates DNA Replication

The cell cycle is a series of events leading to DNA duplication followed by the division of cell content to form two daughter cells. The cell cycle progresses in four stages—the cell increases in size (gap 1 or G1-phase), duplicates its DNA (synthesis or S-phase), prepares to divide (gap 2 or G2-phase), and divides (mitosis or M-phase).
Two states at the origin of replication
In eukaryotes, the initiation of replication occurs at many sites on the chromosomes, called the origins of...
5.2K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.1K