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Features of psychological reactions induced by perampanel: A case report
Shoko M Yamada1, Yusuke Tomita1, Yoshinori Takaya1
1Department of Neurosurgery, Teikyo University Mizonokuchi Hospital, Kanagawa, Japan.
What Is Known And Objective:
Perampanel, an anticonvulsant, might induce psychological reactions.
Case Description:
A 70-year-old woman, who had been taking 2500 mg/day levetiracetam, complained of right-hand minor-convulsion. Perampanel of 2 mg/day was additionally prescribed, and the dosage was increased to 4 mg/day. Two weeks after taking 4 mg/day perampanel, she changed her personality and kept insulting her husband; however, the patient herself was aware of her strange behaviour. She regained her normal personality after quitting the perampanel medication.
What Is New And Conclusion:
This self-awareness is crucial to distinguish the perampanel-induced reaction from psychosis.
