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Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

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Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
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Related Experiment Video

Updated: Dec 21, 2025

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
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Diastolic function in young patients with cryptogenic stroke: A case-control pilot study.

Jani Pirinen1, Jouni Kuusisto2, Vesa Järvinen1

  • 1HUS Medical Imaging Center, Clinical Physiology and Nuclear Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Clinical Physiology and Functional Imaging
|May 15, 2020
PubMed
Summary

Advanced echocardiography revealed subtle diastolic function differences in young cryptogenic stroke patients compared to controls. These findings suggest potential subclinical heart disease in a subgroup of these patients.

Keywords:
4D volumetrybrain infarctionechocardiographystrain imagingstrain rate imaging

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Area of Science:

  • Cardiology
  • Neurology
  • Medical Imaging

Background:

  • Cryptogenic ischemic stroke in young individuals often lacks a clear cause.
  • Investigating subclinical cardiac abnormalities is crucial for understanding stroke etiology.
  • Pilot study to explore diastolic function differences in young stroke patients.

Purpose of the Study:

  • To compare diastolic function between young cryptogenic stroke patients and healthy controls using advanced echocardiography.
  • To identify potential cardiac markers associated with early-onset cryptogenic stroke.
  • To explore if subclinical cardiac abnormalities are present in a subset of young stroke patients.

Main Methods:

  • Recruited 30 young cryptogenic ischemic stroke patients (18-49 years) and 30 age/sex-matched controls.
  • Measured diastolic function using speckle tracking strain rate, Doppler, and 4D volumetry.
  • Analyzed differences, including comparisons of the lowest tertiles for each parameter.

Main Results:

  • No patients or controls met criteria for overt diastolic dysfunction.
  • Stroke patients showed lower E/A ratio, lateral/mean e', A/a' ratio, early diastolic strain rate, and speckle tracking e/a ratio.
  • Lowest tertile analysis revealed lower peak filling rate, peak early filling fraction, and tissue Doppler velocities in patients.

Conclusions:

  • Subtle diastolic function differences exist between young cryptogenic stroke patients and controls.
  • These subtle differences may contribute to the pathogenesis of early-onset cryptogenic stroke.
  • Comparison of lowest tertiles highlights a potential subgroup with subclinical heart disease.