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Microstreaming inside Model Cells Induced by Ultrasound and Microbubbles.

Valerio Pereno¹, Junjun Lei², Dario Carugo³

¹Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford OX3 7DQ, U.K.

Langmuir : the ACS Journal of Surfaces and Colloids

|May 15, 2020

Summary

Ultrasound and microbubbles create internal fluid motion within model cells. This acoustofluidic study reveals insights into intracellular dynamics during ultrasound exposure, crucial for therapeutic applications.

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Published on: January 10, 2017

Area of Science:

Acoustofluidics
Biophysics
Cellular Mechanics

Background:

Ultrasound and microbubble research often overlooks intracellular fluid dynamics.
Understanding intracellular perturbations is key to ultrasound bioeffects.

Purpose of the Study:

Investigate intracellular fluid motion during ultrasound exposure.
Quantify the effects of ultrasound and microbubbles on intracellular streaming.

Main Methods:

Utilized a custom acoustofluidic chamber with giant unilamellar vesicles as model cells.
Tracked fluorescent tracer beads to measure internal fluid dynamics.
Employed numerical modeling with boundary-driven streaming field equations.

Main Results:

Ultrasound, microbubbles, and laminar flow all induced internal streaming within vesicles.
Ultrasound alone generated bead velocities of 6.5 ± 1.3 μm/s.
Microbubbles increased ultrasound-induced velocity to 8.5 ± 3.8 μm/s.

Conclusions:

Acoustofluidic systems can reveal intracellular dynamics.
Further research is needed for mammalian cells in vitro and in vivo.
Findings inform the safety and therapeutic potential of ultrasound treatments.