Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gamma variate fits to pharmacokinetic data.

M Pfeffer1

  • 1Department of Metabolism and Pharmacokinetics, Bristol-Myers Pharmaceutical Research and Development Division, Syracuse, New York 13221.

European Journal of Drug Metabolism and Pharmacokinetics
|July 1, 1988
PubMed
Summary

The gamma variate function shows limitations in fitting pharmacokinetic data. It is best suited for specific extravascular and intravascular profiles, with fitting algorithms requiring careful consideration of deviation minimization for accurate results.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Utility of automated data transfer for cancer clinical trials and considerations for implementation.

ESMO real world data and digital oncology·2026
Same author

Phylogenetic analysis of a novel Hepatozoon species (Hepatozoon sp. SK3) and an additional yet unknown Hepatozoon species (Hepatozoon sp. BV2) besides H. erhardovae in small rodents from Central Europe.

Parasitology research·2024
Same author

Hantavirus-<i>Leptospira</i> coinfections in small mammals from central Germany.

Epidemiology and infection·2021
Same author

Ketogenic diet as a potential intervention for lipedema.

Medical hypotheses·2020
Same author

Survival time of Leptospira kirschneri serovar Grippotyphosa under different environmental conditions.

PloS one·2020
Same author

Field study on bovine paratuberculosis using real-time PCR and liquid culture for testing environmental and individual fecal samples implemented in dairy cow management.

Journal of dairy science·2019

Area of Science:

  • Pharmacokinetics
  • Mathematical Modeling
  • Biopharmaceutics

Background:

  • Pharmacokinetic data analysis often employs mathematical functions to describe drug concentration-time profiles.
  • Polyexponential functions are commonly used, but alternative models like the gamma variate are explored for specific applications.

Purpose of the Study:

  • To evaluate the efficacy of the gamma variate function as a fitting model for pharmacokinetic data.
  • To compare the performance of the gamma variate against polyexponential fits for both intravascular and extravascular datasets.

Main Methods:

  • The gamma variate function (C = At*a*exp(-bt)) was applied to real and simulated pharmacokinetic datasets.
  • Fitting performance was assessed for intravascular and extravascular data, comparing results with polyexponential models.

Related Experiment Videos

  • Analysis included evaluating fits based on minimizing relative deviations versus unweighted sums of squared deviations.

    • Main Results:

    • The gamma variate adequately described some extravascular data, comparable to biexponential models.
    • For intravascular data, the gamma variate's applicability was restricted to a subset of concentration-time profiles.
    • Minimizing relative deviations improved gamma variate fits at high concentrations but led to underestimation of terminal data phases.

    Conclusions:

    • The gamma variate function has limited utility in general pharmacokinetic data fitting.
    • Its application is best suited for specific extravascular profiles and a constrained range of intravascular profiles.
    • Optimal fitting algorithms for the gamma variate require careful selection, particularly regarding deviation minimization strategies.