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The electrogenic Na-K pump does not contribute to endothelium-dependent hyperpolarization in the rabbit ear artery
1Department of Pharmacology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
European Journal of Pharmacology
|November 1, 1988
Abstract:
The application to smooth muscle cells of the rabbit ear artery, of either K ions after incubation with K-free solution, or of ACh produced a transient hyperpolarization of the membrane. Ouabain inhibited the former hyperpolarization but not the latter, indicating that the electrogenic Na-K pump possibly does not contribute to the endothelium-dependent hyperpolarization.