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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Related Experiment Video

Updated: Dec 21, 2025

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
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The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

Published on: April 16, 2019

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Tumor treating fields for high-grade gliomas.

Chengke Luo1, Shengchao Xu1, Gan Dai2

  • 1Department of Neurosurgery, Xiangya Hospital of Central South University, Changsha 410008, Hunan, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|May 15, 2020
PubMed
Summary

Tumor treating fields offer a promising new treatment for high-grade gliomas, improving survival rates. This therapy shows potential for difficult-to-treat brain tumors with fewer side effects.

Keywords:
brain tumorhigh-grade gliomamitotic spindle formationstandard therapytemozolomidetumor treating fields

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Determining the Optimal Inhibitory Frequency for Cancerous Cells Using Tumor Treating Fields TTFields
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Determining the Optimal Inhibitory Frequency for Cancerous Cells Using Tumor Treating Fields TTFields
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Determining the Optimal Inhibitory Frequency for Cancerous Cells Using Tumor Treating Fields TTFields

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Area of Science:

  • Neuro-oncology
  • Medical physics
  • Cancer therapy

Background:

  • High-grade gliomas (HGG) are aggressive brain tumors with poor prognoses.
  • Current treatments for HGG, especially recurrent or drug-resistant cases, are limited.
  • There is a critical need for novel therapeutic strategies for HGG.

Purpose of the Study:

  • To review the mechanism of action of Tumor Treating Fields (TTFields) in glioma cells.
  • To summarize preclinical and clinical evidence supporting TTFields for glioma treatment.
  • To discuss the potential applications, challenges, and future directions of TTFields in neuro-oncology.

Main Methods:

  • Literature review of preclinical studies on TTFields and gliomas.
  • Analysis of clinical trial data for TTFields in glioma patients.
  • Examination of the FDA approval and regulatory status of TTFields.

Main Results:

  • TTFields have demonstrated significant improvements in progression-free survival and overall survival in glioma patients.
  • TTFields represent a novel therapeutic modality with a distinct mechanism of action.
  • The therapy has shown promise as a viable option for recurrent and drug-resistant gliomas.

Conclusions:

  • Tumor Treating Fields show potential as an effective and well-tolerated treatment for high-grade gliomas.
  • Further research is needed to address practical application challenges and optimize TTFields therapy.
  • TTFields may offer a cost-effective therapeutic option with a favorable side effect profile for malignant brain tumors.