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Published on: September 22, 2023
Mangiferin Alleviates Ovalbumin-Induced Allergic Rhinitis via Nrf2/HO-1/NF-κB Signaling Pathways
Chun Hua Piao1, Yan Jing Fan1, Thi Van Nguyen1
1Department of Anatomy, Jeonbuk National University Medical School, Jeounju, Jeonbuk 54896, Korea.
Abstract:
Mangiferin (MF), extracted from mango trees, is considered to have anti-inflammatory, anti-apoptotic, and antioxidant effects. However, its effects on allergic rhinitis (AR), remain unclear. We investigated the mechanisms underlying the protective action of MF in ovalbumin (OVA)-induced AR models. AR was induced by OVA challenge in BALB/c mice. Prior to this, MF and dexamethasone were administered. Mice were examined for nasal mucosal inflammation, the generation of allergen-specific cytokine response, and histopathological changes in the nasal mucosa and lung tissue. MF ameliorated nasal symptoms and nasal mucosa inflammation in OVA-induced AR and reduced inflammatory cell infiltration and epithelial disruption in these tissues. MF inhibited the overproduction of Th2/Th17 cytokines and transcription factors. MF downregulated the HO-1/Nrf2 pathways, reduced oxidative stress biomarker levels, and the NF-κB signaling pathways were inhibited. MF exerts protective effects in AR by inhibiting NF-κB and activating HO-1/Nrf2 pathways. MF could be used for the treatment of AR.
Insights
Mangiferin (MF) effectively treats allergic rhinitis (AR) by reducing nasal inflammation and inhibiting key inflammatory pathways. This mango extract shows promise for AR treatment by modulating immune responses and oxidative stress.
Area of Science:
- Immunology
- Pharmacology
- Natural Products Chemistry
Background:
- Allergic rhinitis (AR) is a common inflammatory condition affecting the nasal mucosa.
- Mangiferin (MF), a natural compound from mango trees, possesses known anti-inflammatory and antioxidant properties.
- The therapeutic potential of MF for AR remains largely unexplored.
Purpose of the Study:
- To investigate the protective mechanisms of mangiferin (MF) in a mouse model of ovalbumin (OVA)-induced allergic rhinitis (AR).
- To evaluate the effects of MF on nasal inflammation, immune responses, and related molecular pathways in AR.
Main Methods:
- Allergic rhinitis was induced in BALB/c mice using ovalbumin (OVA) challenge.
- Mice were pretreated with mangiferin (MF) or dexamethasone.
- Evaluated nasal mucosal inflammation, cytokine profiles (Th2/Th17), histopathological changes, oxidative stress biomarkers, and key signaling pathways (NF-κB, HO-1/Nrf2).
Main Results:
- MF significantly ameliorated nasal symptoms and inflammation in OVA-induced AR.
- MF reduced inflammatory cell infiltration and epithelial damage in nasal mucosa and lung tissues.
- MF inhibited Th2/Th17 cytokine and transcription factor overproduction, downregulated HO-1/Nrf2 pathways, reduced oxidative stress, and inhibited NF-κB signaling.
Conclusions:
- Mangiferin exerts protective effects against allergic rhinitis by inhibiting the NF-κB pathway and activating the HO-1/Nrf2 pathways.
- MF demonstrates potential as a therapeutic agent for treating allergic rhinitis due to its anti-inflammatory and antioxidant actions.
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