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First report on multidrug-resistant non-encapsulated Streptococcus pneumoniae isolated from a patient with pneumonia
Noriko Takeuchi1, Misako Ohkusu1, Haruka Hishiki2
1Department of Infectious Diseases, Medical Mycology Research Center, Chiba University, Chiba, Japan.
Abstract:
The non-encapsulated Streptococcus pneumoniae (NESp) has emerged and increased in the clinical setting. The majority of NESp strains have been isolated from the nasopharynxes of healthy carriers and from respiratory specimens of patients with otitis media. NESp strains were shown to be more effective than encapsulated counterparts at forming biofilms. Therefore, NESp should become one of the leading causes of emerging refractory respiratory disease after the introduction of pneumococcal conjugate vaccines. We report the first case of multidrug-resistant - including fluoroquinolone-resistant - NESp isolated from the intrabronchial aspirate of a patient with pneumonia. Drug-resistant NESp infections can possibly emerge as a clinical problem and thus the continuous monitoring of NESp infections is of utmost importance.
Insights
Non-encapsulated Streptococcus pneumoniae (NESp) is an emerging pathogen, particularly in respiratory infections. This study reports the first multidrug-resistant NEsp case, highlighting the need for ongoing surveillance.
Area of Science:
- Microbiology
- Infectious Diseases
- Clinical Medicine
Background:
- Non-encapsulated Streptococcus pneumoniae (NESp) is increasingly identified in clinical settings.
- NESp strains are frequently isolated from healthy carriers and otitis media patients.
- NESp exhibits enhanced biofilm formation compared to encapsulated strains.
Observation:
- This study details the first isolation of multidrug-resistant NEsp, including fluoroquinolone resistance.
- The resistant NEsp strain was identified in an intrabronchial aspirate from a pneumonia patient.
Findings:
- Non-encapsulated Streptococcus pneumoniae demonstrates increased prevalence.
- NESp possesses superior biofilm-forming capabilities over encapsulated variants.
- Emergence of multidrug-resistant NEsp, including fluoroquinolone resistance, is a significant clinical concern.
Implications:
- NESp may become a leading cause of refractory respiratory diseases post-vaccine introduction.
- Drug-resistant NEsp infections pose a potential future clinical challenge.
- Continuous monitoring of NEsp infections is crucial for public health management.
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