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Updated: Dec 21, 2025

Noninvasive, High-throughput Determination of Sleep Duration in Rodents
Published on: April 18, 2018
SMPD1 variants do not have a major role in rapid eye movement sleep behavior disorder
Uladzislau Rudakou1, Naomi C Futhey2, Lynne Krohn1
1Department of Human Genetics, McGill University, Montréal, Quebec, Canada; Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada.
Abstract:
Mutations in the sphingomyelin phosphodiesterase 1 (SMPD1) gene were reported to be associated with Parkinson's disease and dementia with Lewy bodies. In the current study, we aimed to evaluate the role of SMPD1 variants in isolated rapid eye movement sleep behavior disorder (iRBD). SMPD1 and its untranslated regions were sequenced using targeted next-generation sequencing in 959 iRBD patients and 1287 controls from European descent. Our study reports no statistically significant association of SMPD1 variants and iRBD. It is hence unlikely that SMPD1 plays a major role in iRBD.
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