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Related Concept Videos

Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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Antibody Structure and Classes01:25

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Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
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Antibody Structure01:10

Antibody Structure

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Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
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Antibody Actions01:26

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Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
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Related Experiment Video

Updated: Dec 21, 2025

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing
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Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

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How repertoire data are changing antibody science.

Claire Marks1, Charlotte M Deane2

  • 1Department of Statistics, University of Oxford, Oxford, United Kingdom.

The Journal of Biological Chemistry
|May 16, 2020
PubMed
Summary

Antibody sequencing reveals immune system status and potential for new therapeutics. Analyzing B-cell receptor repertoires offers insights into immune responses and disease treatment strategies.

Keywords:
B-cell receptor (BCR)adaptive immunityantibodybioinformaticsimmunologynext-generation sequencingobserved antibody space databaseprotein sequenceprotein structurestructural annotation

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Area of Science:

  • Immunology
  • Bioinformatics
  • Structural Biology

Background:

  • Antibodies are crucial immune proteins recognizing and eliminating harmful molecules.
  • Mammals generate diverse antibodies for high-affinity antigen binding, enabling therapeutic applications.
  • Antibody repertoires reflect an organism's immune status and past exposures.

Purpose of the Study:

  • To review the exploitation of B-cell receptor (BCR) repertoire data.
  • To highlight insights into naive immune repertoire generation and antigen response.
  • To explore structural data integration for enhanced sequence space depiction and therapeutic discovery.

Main Methods:

  • Utilizing next-generation sequencing to analyze antibody (BCR) sequence repertoires.
  • Leveraging large public databases like Observed Antibody Space containing billions of sequences.
  • Integrating structural information with sequence data.

Main Results:

  • BCR repertoire data provide insights into immune system status and responses.
  • Vast amounts of BCR sequence data are available from diverse studies and conditions.
  • Structural data can refine sequence space representations.

Conclusions:

  • BCR repertoire analysis offers significant opportunities to understand immunity.
  • Exploiting this data can lead to improved depictions of immune sequence space.
  • Applications include the discovery of novel antibody-based therapeutics.