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Updated: Dec 21, 2025

Assessment of Bone Fracture Healing Using Micro-Computed Tomography
Published on: December 9, 2022
[Radiologic diagnosis of pathologic fractures]
Felix Wuennemann1, Laurent Kintzelé2, Marc-André Weber3
1Diagnostische und Interventionelle Radiologie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Deutschland. felix.wuennemann@med.uni-heidelberg.de.
Pathologic fractures, often caused by bone lesions or metastases, require accurate imaging for diagnosis. This review details imaging characteristics and introduces risk assessment scores like Mirels' and SINS.
Area of Science:
- Radiology
- Orthopedics
- Oncology
Background:
- Pathologic fractures result from skeletal lesions, not trauma.
- Osseous metastases are an increasing cause due to aging populations and cancer treatment advances.
- Differentiating pathologic from stress or insufficiency fractures is vital for treatment.
Purpose of the Study:
- To elucidate the imaging features of pathologic fractures.
- To define the role of imaging in suspected cases.
- To introduce fracture risk assessment tools: Mirels' score and Spinal Instability Neoplastic Score (SINS).
Main Methods:
- Comprehensive PubMed literature search.
- Keywords included "pathologic fracture", "imaging", "fracture risk", "bone metastases", "Mirels' score", and "SINS".
- Review focused on diagnostic imaging and risk stratification.
Main Results:
- Definitions of pathologic, fatigue, and insufficiency fractures are provided.
- The utility of imaging in diagnosing and differentiating fracture types is explained.
- Common scoring systems for assessing fracture risk are described.
Conclusions:
- Accurate imaging is crucial for diagnosing pathologic fractures.
- Risk assessment scores aid in management planning for bony lesions.
- Understanding fracture types ensures appropriate patient treatment.
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