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Updated: Dec 21, 2025
05:20
Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration
Published on: March 31, 2023
1.6K
[Circular RNA expression pattern and competing endogenous RNA network involved in rotator cuff tendinopathy]
Zilu Ge1, Binghua Zhou1, Xiaolong Zheng1
1Department of Orthopeadics/Sports Medicine Center, the First Affiliated Hospital of the Army Medical University, Chongqing, 400038, P.R.China.
Summary
This study identified 94 differentially expressed circular RNAs (circRNAs) in rotator cuff tendinopathy, revealing potential therapeutic targets for improved treatment and prevention strategies.
Area of Science:
- Biochemistry
- Molecular Biology
- Genomics
Background:
- Rotator cuff tendinopathy is a common debilitating condition.
- Understanding the molecular mechanisms underlying tendinopathy is crucial for developing effective treatments.
Purpose of the Study:
- To identify differentially expressed circular RNAs (circRNAs) in rotator cuff tendinopathy.
- To elucidate the potential molecular mechanisms involving parental genes of these circRNAs.
Main Methods:
- RNA sequencing was performed on supraspinatus tendon samples from patients with rotator cuff tendinopathy and healthy controls.
- Bioinformatic analyses included Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, and competing endogenous RNA (ceRNA) network construction.
Main Results:
- 94 differentially expressed circRNAs were identified (31 up-regulated, 63 down-regulated).
- GO analysis indicated enrichment in cyclic adenosine monophosphate (cAMP) response.
- KEGG analysis highlighted pathways such as extracellular matrix-receptor interaction and nuclear factor κB signaling.
Conclusions:
- This study identified novel circRNAs associated with rotator cuff tendinopathy.
- These findings offer potential therapeutic targets for the treatment and prevention of rotator cuff tendinopathy.
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