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Interaction of bone and brain: osteocalcin and cognition
Misa Nakamura1,2, Masakazu Imaoka1,2, Masatoshi Takeda2
1Department of Rehabilitation, Osaka Kawasaki Rehabilitation University, Kaizuka, Osaka, Japan.
The International Journal of Neuroscience
|May 16, 2020
Summary
Bone produces osteocalcin (OC), an important hormone regulating metabolism. Declining OC levels with aging may impair cognitive function, but exercise can help improve it.
Area of Science:
- Endocrinology
- Neuroscience
- Gerontology
Background:
- Bone is an endocrine organ regulating systemic metabolism via osteocalcin (OC).
- Osteocalcin plays a crucial role in the brain-bone axis.
Purpose of the Study:
- To explore the relationship between the brain and bone.
- To summarize the effects of OC on cognitive function.
- To investigate the association between OC, exercise, and cognitive function.
Main Methods:
- Review of existing research on osteocalcin and cognitive function.
- Analysis of studies examining the impact of exercise on cognition in aging populations.
- Focus on the interplay between bone health and brain function.
Main Results:
- Decreased osteocalcin production in aging is linked to cognitive decline.
- Exercise interventions show positive effects on cognitive function in the elderly and those with mild cognitive impairment (MCI).
- Moderate exercise is particularly effective for dementia prevention.
Conclusions:
- Improving bone health in aging individuals may enhance cognitive function.
- Maintaining adequate osteocalcin levels is crucial for preserving cognitive abilities.
- Exercise is a viable strategy to support brain health and prevent cognitive decline.
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