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Updated: Dec 21, 2025

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Published on: February 12, 2017
Baseline quality of life is associated with survival among people with advanced lung cancer
Mario J Trejo1, Melanie L Bell1, Haryana M Dhillon2
1Department Epidemiology and Biostatistics, Mel & Enid Zuckerman College of Public Health, The University of Arizona, Tucson, Arizona, USA.
Introduction:
Lung cancer patients presenting with advanced cancer face low survival rates and a high symptom burden. There have been mixed findings for the association between survival and various patient reported outcomes (PROs).
Methods:
We used prospective data from 111 lung cancer patients with advanced stage III/IV disease to investigate the association of survival with PROs (European Organization for Research and Treatment of Cancer Core-30 and Lung Module). Cox proportional hazard models were used to examine the individual association between several PRO measures and survival.
Results:
Pain in chest and global quality of life (QoL) were found to have the strongest association with survival with a 20% increased hazard of death per 10% increase in pain in chest and 14% decrease in hazard of death per 10% increase in global QoL.
Conclusion:
Our results provide more evidence for the value of PRO data to inform clinical and patient decision-making.
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