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Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
Published on: October 29, 2015
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Emerging pharmacotherapies for COVID-19
Rachana Salvi1, Panini Patankar1
1Department of Pharmacology & Therapeutics, Seth GSMC & KEM Hospital, Mumbai, 400012, India.
Summary
Repurposed drugs like hydroxychloroquine and Remdesivir show promise for treating novel coronavirus disease 2019 (COVID-19). Research is ongoing for anti-inflammatory treatments and vaccines to combat the pandemic.
Area of Science:
- * Virology and Infectious Diseases
- * Clinical Pharmacology and Therapeutics
Background:
- * Novel Corona-virus Disease 2019 (COVID-19) is a severe respiratory illness with high mortality.
- * The pandemic declared by WHO on March 12, 2020, has affected over 1.5 million globally.
- * No definitive therapy or vaccine exists, necessitating exploration of repurposed drugs and novel treatments.
Purpose of the Study:
- * To review current evidence on the efficacy of repurposed drugs for COVID-19 treatment.
- * To discuss ongoing research into anti-inflammatory therapies targeting cytokine storm.
- * To provide an overview of potential therapeutic strategies for COVID-19.
Main Methods:
- * Review of current scientific literature and ongoing clinical trials, including the WHO SOLIDARITY trial.
- * Analysis of evidence for repurposed medications such as anti-malarials and anti-HIV drugs.
- * Investigation into the role of anti-inflammatory agents and cytokines in COVID-19 pathogenesis.
Main Results:
- * Repurposed drugs including chloroquine phosphate, hydroxychloroquine, Remdesivir, and Lopinavir-Ritonavir show potential efficacy.
- * Convalescent plasma therapy is also under investigation.
- * Anti-inflammatory drugs (Anakinra, Tocilizumab) and cytokines (IL-37, IL-38) demonstrate encouraging preliminary results in trials.
Conclusions:
- * Repurposed medications offer a viable treatment option for COVID-19 in the absence of definitive therapies and vaccines.
- * Targeting the inflammatory response, particularly cytokine storm, is a promising therapeutic avenue.
- * Continued research and clinical trials are crucial for developing effective COVID-19 treatments.
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