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Updated: Dec 21, 2025

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
Published on: December 10, 2012
Adaptive Incremental Mixture Markov Chain Monte Carlo
Florian Maire1, Nial Friel2,3, Antonietta Mira4,5
1Département de Mathématiques et de Statistique, Université de Montréal, Montréal, Quebec, Canada.
Abstract:
We propose adaptive incremental mixture Markov chain Monte Carlo (AIMM), a novel approach to sample from challenging probability distributions defined on a general state-space. While adaptive MCMC methods usually update a parametric proposal kernel with a global rule, AIMM locally adapts a semiparametric kernel. AIMM is based on an independent Metropolis-Hastings proposal distribution which takes the form of a finite mixture of Gaussian distributions. Central to this approach is the idea that the proposal distribution adapts to the target by locally adding a mixture component when the discrepancy between the proposal mixture and the target is deemed to be too large. As a result, the number of components in the mixture proposal is not fixed in advance. Theoretically, we prove that there exists a stochastic process that can be made arbitrarily close to AIMM and that converges to the correct target distribution. We also illustrate that it performs well in practice in a variety of challenging situations, including high-dimensional and multimodal target distributions. Finally, the methodology is successfully applied to two real data examples, including the Bayesian inference of a semiparametric regression model for the Boston Housing dataset. Supplementary materials for this article are available online.
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