Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

226
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
226
Multi-input and Multi-variable systems01:22

Multi-input and Multi-variable systems

325
Cruise control systems in cars are designed as multi-input systems to maintain a driver's desired speed while compensating for external disturbances such as changes in terrain. The block diagram for a cruise control system typically includes two main inputs: the desired speed set by the driver and any external disturbances, such as the incline of the road. By adjusting the engine throttle, the system maintains the vehicle's speed as close to the desired value as possible.
In the absence of...
325
Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

192
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
192
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

203
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
203
Radical Anti-Markovnikov Addition to Alkenes: Mechanism01:17

Radical Anti-Markovnikov Addition to Alkenes: Mechanism

4.5K
The reaction of hydrogen bromide with alkenes in the presence of hydroperoxides or peroxides proceeds via anti-Markovnikov addition. The radical chain reaction comprises initiation, propagation, and termination steps.
The mechanism starts with chain initiation, which involves two steps. In the first chain initiation step, a weak peroxide bond is homolytically cleaved upon mild heating to form two alkoxy radicals. In the second initiation step, a hydrogen atom is abstracted by the alkoxy...
4.5K
Per-Unit Sequence Models01:26

Per-Unit Sequence Models

362
An ideal Y-Y transformer, grounded through neutral impedances, displays per-unit sequence networks akin to those of a single-phase ideal transformer when subjected to balanced positive- or negative-sequence currents. These currents do not produce neutral currents, and their associated voltage drops.
Zero-sequence currents, which are identical in magnitude and phase, generate a neutral current, resulting in voltage drops across the neutral impedance and the low-voltage winding. If the...
362

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A stochastic block prior for clustering in graphical models.

Psychological methods·2026
Same author

Bayesian uncertainty quantification to identify population level vaccine hesitancy behaviours.

PloS one·2026
Same author

Comparing variable selection and model averaging methods for logistic regression.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Bringing Age Back In: Accounting for Population Age Distribution in Forecasting Migration.

Demography·2026
Same author

Scale adaptive and robust intrinsic dimension estimation via optimal neighbourhood identification.

Scientific reports·2026
Same author

A general framework for adaptive nonparametric dimensionality reduction.

Scientific reports·2026
Same journal

Probabilistic Joint and Individual Variation Explained (ProJIVE) for Data Integration.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·2026
Same journal

fastkqr: A Fast Algorithm for Kernel Quantile Regression.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·2026
Same journal

Empirical Bayes Covariance Decomposition, and a Solution to the Multiple Tuning Problem in Sparse PCA.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·2026
Same journal

Joint Registration and Conformal Prediction for Partially Observed Functional Data.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·2026
Same journal

Efficient Decision Trees for Tensor Regressions.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·2026
Same journal

Distributed Nonparametric Regression with Heterogeneity Through Prediction-Based Aggregation.

Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America·2026
See all related articles

Related Experiment Video

Updated: Dec 21, 2025

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
12:39

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types

Published on: December 10, 2012

11.6K

Adaptive Incremental Mixture Markov Chain Monte Carlo.

Florian Maire1, Nial Friel2,3, Antonietta Mira4,5

  • 1Département de Mathématiques et de Statistique, Université de Montréal, Montréal, Quebec, Canada.

Journal of Computational and Graphical Statistics : a Joint Publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America
|May 16, 2020
PubMed
Summary
This summary is machine-generated.

We introduce adaptive incremental mixture Markov chain Monte Carlo (AIMM), a new method for sampling complex probability distributions. AIMM locally adapts its proposal distribution, improving performance on challenging, high-dimensional, and multimodal targets.

Keywords:
Adaptive MCMCBayesian inferenceImportance weightIndependence samplerLocal adaptation

More Related Videos

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion
09:17

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Published on: March 1, 2022

3.5K
Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

335

Related Experiment Videos

Last Updated: Dec 21, 2025

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
12:39

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types

Published on: December 10, 2012

11.6K
Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion
09:17

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Published on: March 1, 2022

3.5K
Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

335

Area of Science:

  • Computational Statistics
  • Bayesian Inference
  • Machine Learning

Background:

  • Markov chain Monte Carlo (MCMC) methods are crucial for Bayesian inference.
  • Adaptive MCMC methods often use global updates, which can be inefficient for complex distributions.
  • Existing methods struggle with high-dimensional and multimodal target distributions.

Purpose of the Study:

  • To propose a novel adaptive MCMC algorithm, AIMM, for sampling from challenging probability distributions.
  • To develop a method that locally adapts a semiparametric proposal kernel.
  • To address limitations of global adaptation rules in existing adaptive MCMC techniques.

Main Methods:

  • AIMM utilizes an independent Metropolis-Hastings proposal based on a finite mixture of Gaussian distributions.
  • The algorithm locally adapts by adding mixture components when discrepancies with the target distribution are detected.
  • The number of mixture components is not fixed a priori, allowing for dynamic adaptation.

Main Results:

  • Theoretical guarantees show a related stochastic process converges to the correct target distribution.
  • Empirical results demonstrate AIMM's effectiveness on high-dimensional and multimodal distributions.
  • Successful application to Bayesian inference for a semiparametric regression model on the Boston Housing dataset.

Conclusions:

  • AIMM offers a flexible and effective approach for sampling from difficult probability distributions.
  • The local adaptation strategy enhances performance in complex scenarios.
  • The method shows practical utility in real-world Bayesian inference problems.