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Related Concept Videos

Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

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Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
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Related Experiment Video

Updated: Dec 21, 2025

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
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Neurovascular Unit Dysfunction and Neurodegenerative Disorders.

Xing Yu1, Caihong Ji2, Anwen Shao3

  • 1Department of Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Frontiers in Neuroscience
|May 16, 2020
PubMed
Summary

The neurovascular unit (NVU) is crucial for brain health, regulating blood flow and the blood-brain barrier. NVU dysfunction is linked to neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS, offering potential therapeutic targets.

Keywords:
Alzheimer’s diseaseblood–brain barrierneurodegenerative diseaseneurovascular unittarget

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Area of Science:

  • Neuroscience
  • Vascular Biology
  • Neurodegenerative Diseases

Background:

  • The neurovascular unit (NVU), comprising vascular cells, glial cells, and neurons, is essential for brain function.
  • The NVU maintains blood-brain barrier (BBB) integrity and regulates cerebral blood flow (CBF).
  • Dysfunction in the NVU, including BBB breakdown and reduced CBF, is an early indicator in Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS).

Purpose of the Study:

  • To review the role of the neurovascular unit (NVU) in the pathophysiology of neurodegenerative diseases.
  • To focus on the NVU's involvement in Alzheimer's disease (AD) due to extensive research.
  • To explore NVU dysfunction in Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS).

Main Methods:

  • Literature review focusing on the neurovascular unit (NVU).
  • Analysis of studies linking NVU dysfunction to Alzheimer's disease (AD).
  • Examination of the role of NVU dysfunction in Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS) pathogenesis.

Main Results:

  • Neurovascular unit (NVU) dysfunction, including blood-brain barrier (BBB) compromise and altered cerebral blood flow (CBF), is a common early feature in major neurodegenerative diseases.
  • Significant evidence links NVU dysfunction to the progression of Alzheimer's disease (AD).
  • NVU dysfunction also plays a critical role in the pathological mechanisms of Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS).

Conclusions:

  • The neurovascular unit (NVU) is a critical factor in maintaining brain health and is implicated in neurodegenerative diseases.
  • Targeting the NVU presents a promising avenue for developing novel therapeutic strategies for Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS).
  • Vascular-targeted therapies focusing on the NVU may offer new treatment options for these currently difficult-to-treat conditions.