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Updated: Dec 21, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
A Natural Language Interface for Dissemination of Reproducible Biomedical Data Science
Rogers Jeffrey Leo John1, Jignesh M Patel1, Andrew L Alexander1
1University of Wisconsin-Madison, Madison, USA.
Abstract:
Computational tools in the form of software packages are burgeoning in the field of medical imaging and biomedical research. These tools enable biomedical researchers to analyze a variety of data using modern machine learning and statistical analysis techniques. While these publicly available software packages are a great step towards a multiplicative increase in the biomedical research productivity, there are still many open issues related to validation and reproducibility of the results. A key gap is that while scientists can validate domain insights that are implicit in the analysis, the analysis itself is coded in a programming language and that domain scientist may not be a programmer. Thus, there is no/limited direct validation of the program that carries out the desired analysis. We propose a novel solution, building upon recent successes in natural language understanding, to address this problem. Our platform allows researchers to perform, share, reproduce and interpret the analysis pipelines and results via natural language. While this approach still requires users to have a conceptual understanding of the techniques, it removes the burden of programming syntax and thus lowers the barriers to advanced and reproducible neuroimaging and biomedical research.
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