Barrier lymphocytes in spondyloarthritis
Adam Berlinberg1, Kristine A Kuhn
1Division of Rheumatology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Current Opinion in Rheumatology
|May 16, 2020
Summary
Barrier tissue immunity, particularly involving specific lymphocyte populations like T cells, plays a key role in spondyloarthritis (SpA) development. These cells produce interleukin-17, contributing to SpA pathogenesis.
Area of Science:
- Immunology
- Rheumatology
- Microbiology
Background:
- Spondyloarthritis (SpA) shares clinical features with barrier tissue inflammation (gut, skin).
- Barrier tissue immunity is implicated in SpA development.
- Understanding these immune mechanisms is crucial for SpA research.
Purpose of the Study:
- To review recent advances in lymphocyte populations and functions in the intestine and skin.
- To elucidate the role of barrier tissue immunity in SpA pathophysiology.
- To identify potential therapeutic targets for SpA.
Main Methods:
- Literature review of recent advances in SpA research.
- Focus on lymphocyte populations in barrier tissues (gut, skin).
- Analysis of cellular functions and cytokine production (IL-17).
Main Results:
- Expansion of unique lymphocyte populations in SpA patients: gamma-delta T cells, mucosa-associated invariant T (MAIT) cells, innate lymphoid cells (ILCs), and T resident memory (TRM) cells.
- These lymphocytes respond to microbial cues at barrier surfaces.
- Cellular activation leads to interleukin-17 (IL-17) production, a proposed mechanism in SpA pathogenesis.
Conclusions:
- Unique lymphocyte populations and their IL-17 production are central to SpA development.
- Insights into SpA pathophysiology are gained through understanding these immune cells.
- Potential future therapeutic strategies targeting these pathways can be developed.
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