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Cell Lineage Tracing and Cellular Diversity in Humans
Alexej Abyzov1, Flora M Vaccarino2
1Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA;
Annual Review of Genomics and Human Genetics
|May 16, 2020
Summary
Scientists can now trace human cell lineages using natural DNA and methylation variations, paving the way for a detailed human developmental map. This approach overcomes ethical limitations of experimental tracing.
Area of Science:
- Developmental Biology
- Genetics
- Genomics
Background:
- Cell lineage tracing is crucial for understanding organism development and cell differentiation.
- Experimental lineage tracing in humans is ethically restricted.
- Natural variations in DNA and methylation offer alternative lineage tracing markers.
Purpose of the Study:
- To review current methods and markers for human cell lineage tracing.
- To discuss the advantages and disadvantages of various lineage tracing approaches.
- To outline a conceptual framework for creating a human cell lineage map.
Main Methods:
- Utilizing natural variations in nuclear and mitochondrial DNA.
- Analyzing DNA methylation status for lineage information.
- Leveraging data from normal, noncancerous cells.
Main Results:
- Recent studies show feasibility of lineage tracing using natural variations.
- Multiple data types (DNA, methylation) can be employed.
- A comprehensive human embryonic and fetal development map is becoming attainable.
Conclusions:
- Natural mutation markers provide a viable alternative to experimental lineage tracing in humans.
- The development of a detailed human cell lineage map is on the horizon.
- This review provides insights into current techniques and future directions for human lineage mapping.
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