Vitamin D and advanced glycation end products and their receptors

Area of Science:

• Biochemistry
• Endocrinology
• Nutrition Science

Background:

• Advanced glycation end products (AGEs) are implicated in chronic disease progression.
• Vitamin D's role in modulating AGEs and their receptors (RAGE, sRAGE) is under investigation.
• Understanding this interaction is crucial for managing AGE-related pathologies.

Purpose of the Study:

• To systematically review and summarize the effects of vitamin D on AGEs, RAGE, and sRAGE.
• To elucidate the potential benefits and risks of vitamin D in AGE-RAGE system modulation.
• To identify signaling pathways involved in vitamin D's effects on AGE receptors.

Main Methods:

• Systematic literature search identifying 484 articles.
• Duplicate removal and screening resulted in 35 relevant articles.
• Final analysis included 27 articles after critical appraisal.

Main Results:

• Vitamin D supplementation may reduce AGE levels and increase sRAGE, particularly in vitamin D-deficient individuals.
• Vitamin D might decrease RAGE expression in certain diseases but could be detrimental under normal conditions.
• Vitamin D's effects on AGE receptors are mediated by pathways including MAPK/NF-κB, ADAM10/MMP9, and AT1R.

Conclusions:

• Vitamin D supplementation can be a beneficial strategy for managing AGE-mediated complications in chronic diseases with concurrent hypovitaminosis D.
• Modulating the AGE-RAGE and sRAGE systems with vitamin D shows promise for ameliorating disease progression.
• Careful consideration of vitamin D's dual effects on RAGE is necessary, depending on the physiological context.