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[Voriconazole-induced lentigines on photo-exposed skin: A little-known complication]

M Marcaillou1, A Brun1, J Mazereeuw-Hautier1

  • 1Service de dermatologie, Centre des maladies rares de la peau, CHU Larrey Toulouse, 24, chemin de Pouvourville, 31400 Toulouse, France.

Annales De Dermatologie Et De Venereologie
|May 17, 2020
PubMed
Abstract

Insights

Voriconazole can cause sun-exposed skin spots (lentigines) in children, appearing rapidly. This rare side effect necessitates careful drug risk assessment and sun protection for pediatric patients.

Area of Science:

  • Pediatric Dermatology
  • Pharmacovigilance
  • Mycology

Background:

  • Diffuse lentigines in children are rare, often suggesting genetic syndromes.
  • Voriconazole, an antifungal, is a less common cause of photo-distributed lentigines.
  • This report highlights a unique case with an exceptionally short onset of symptoms.

Observation:

  • A 9-year-old immunosuppressed female developed lentigines on sun-exposed skin.
  • The patient was undergoing treatment with voriconazole for 3 months.
  • Lentigines appeared after only 4 weeks of voriconazole exposure.

Findings:

  • The case adds to a small number of reported pediatric instances of voriconazole-induced photo-distributed lentigines.
  • The onset of this side effect can be very rapid.
  • Voriconazole is also linked to increased risks of cutaneous squamous cell carcinomas and melanoma.

Implications:

  • The benefit-risk ratio of prescribing voriconazole in children requires careful evaluation.
  • Close clinical monitoring for skin changes is crucial in pediatric patients on voriconazole.
  • Strict photoprotection measures are essential for children treated with voriconazole.
Keywords:
LentiginesPhototoxicityPhototoxicitéVoriconazole

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