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Depression could modulate neuropsychological status in epilepsy
N Forthoffer1, C Kleitz2, M Bilger2
1Service de Neurologie, Centre Hospitalier Universitaire de Nancy, 54000 Nancy, France; LNCA, UMR 7364, CNRS et Université de Strasbourg, Strasbourg, France.
Revue Neurologique
|May 17, 2020
Summary
Depression significantly impacts cognition in epilepsy patients, varying with seizure origin and epilepsy type. Early depression assessment is crucial for managing cognitive decline, especially before epilepsy surgery.
Area of Science:
- Neurology
- Neuropsychology
- Psychiatry
Background:
- Cognition and depression are frequently studied in epilepsy, but their specific interrelationship remains underexplored.
- Few studies have investigated the direct impact of depression on cognitive function in patients with epilepsy (PWE).
Purpose of the Study:
- To review and synthesize existing literature on the impact of depression on cognition in PWE.
- To understand how factors like seizure laterality, epilepsy type, and surgical context influence this relationship.
Main Methods:
- Extensive literature search of databases for relevant studies.
- Inclusion criteria: adult PWE, quantitative depression/neuropsychological assessment, statistical analysis of depression's impact on cognition, studies with >= 20 patients.
- Narrative and descriptive summary of findings from 20 selected articles.
Main Results:
- Depression has a variable impact on cognition in PWE.
- The effect of depression on cognition is influenced by seizure onset zone laterality, epilepsy type, and surgical context.
- Studies indicate a need for systematic depression screening in PWE.
Conclusions:
- Depression significantly affects cognitive function in patients with epilepsy.
- Prompt depression assessment and care are vital for PWE to prevent cognitive decline, particularly in those undergoing or considering surgery.
- Further research is needed to elucidate the complex interplay between depression, epilepsy characteristics, and cognitive outcomes.
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