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Research Progress on Long Non-coding RNAs and Drug Resistance of Breast Cancer

Xiping Zhang1, Hongjian Yang1

  • 1Department of Breast Surgery, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, China.

Clinical Breast Cancer
|May 17, 2020
PubMed

Insights

Long non-coding RNAs (LncRNAs) are linked to breast cancer drug resistance. Understanding LncRNA mechanisms could lead to new diagnostic markers and therapeutic targets for this deadly disease.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Breast cancer is a leading cause of cancer death in women, characterized by metastasis and mutability.
  • Drug resistance to chemotherapy, endocrine, and targeted therapies significantly worsens breast cancer patient prognosis.
  • Long non-coding RNAs (LncRNAs) are key regulators of gene expression with emerging roles in cancer biology.

Purpose of the Study:

  • To summarize current research on the relationship between LncRNAs and drug resistance in breast cancer.
  • To elucidate the molecular mechanisms by which LncRNAs influence breast cancer drug resistance.
  • To discuss the potential of LncRNAs as predictive biomarkers and therapeutic targets for breast cancer.

Main Methods:

  • Literature review of studies investigating LncRNA expression and function in breast cancer.
  • Analysis of molecular pathways regulated by LncRNAs in the context of drug resistance.
  • Synthesis of findings on LncRNA's role in processes like drug transport, apoptosis, and EMT.

Main Results:

  • LncRNA expression levels correlate with breast cancer prognosis and drug resistance.
  • LncRNAs modulate critical signaling pathways involved in multi-drug resistance (MDR1), NRF2, PI3K/Akt/mTOR, TGF-β, BRCA1/2, and NF-κB.
  • LncRNAs impact biological processes including drug transport, detoxification, apoptosis, epithelial-to-mesenchymal transition (EMT), and autophagy.

Conclusions:

  • LncRNAs play a significant role in the development and progression of breast cancer drug resistance.
  • LncRNAs hold promise as molecular markers for predicting drug resistance in breast cancer patients.
  • Targeting LncRNAs presents a potential novel therapeutic strategy for overcoming drug resistance in breast cancer.
Keywords:
Breast cancerDrug resistanceEpithelial to mesenchymal transitions (EMT)Long non-coding ribonucleic acids (LncRNAs)Molecular mechanisms

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