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Combination of ceftaroline and daptomycin as treatment for complicated osteomyelitis

Ana Gascón1, Marta Castresana2, Natalia Alzueta3

  • 1Pharmacy, Hospital Reina Sofia Navarre Health Service, Tudela, Spain am.gascon.villacampa@navarra.es.

European Journal of Hospital Pharmacy : Science and Practice
|May 17, 2020
PubMed

Insights

This case report details a successful treatment for bone infection (osteomyelitis) caused by methicillin-resistant Staphylococcus epidermidis (MRSE). A combination of daptomycin and ceftaroline proved effective, offering a new therapeutic option.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Microbiology

Background:

  • Osteomyelitis is a bone infection often caused by Staphylococcus bacteria.
  • Methicillin-resistant staphylococci (MRS) present treatment challenges.
  • Vancomycin is a common treatment, but alternatives are explored.

Observation:

  • A 54-year-old woman had osteomyelitis caused by methicillin-resistant Staphylococcus epidermidis (MRSE).
  • Previous treatments for MRS osteomyelitis can be difficult to manage.
  • The patient was treated with a combination of daptomycin and ceftaroline.

Findings:

  • The combination of daptomycin and ceftaroline was successfully used to treat MRSE osteomyelitis.
  • This antibiotic regimen offers an alternative to standard treatments.
  • The clinical pharmacist played a key role in antimicrobial stewardship.

Implications:

  • This combination therapy may be a viable option for MRSE infections.
  • Further research into daptomycin and ceftaroline for resistant staphylococcal infections is warranted.
  • Highlights the importance of clinical pharmacists in managing complex infections.
Keywords:
hospital pharmacy educationinfection controlmicrobiological controlmicrobiologypharmacokinetics and dynamics

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