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2019-Novel Coronavirus-Related Acute Cardiac Injury Cannot Be Ignored

Yueying Wang1, Leonardo Roever2, Gary Tse1

  • 1Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, 300211, People's Republic of China.

Current Atherosclerosis Reports
|May 17, 2020
PubMed

Insights

COVID-19, caused by SARS-CoV-2, can lead to cardiac injury. This review summarizes the prevalence and mechanisms of acute cardiac injury in COVID-19 patients, highlighting the role of ACE2 receptors.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Virology

Background:

  • Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is a global pandemic.
  • While primarily respiratory, SARS-CoV-2 infection is associated with cardiac injury.
  • Cardiac injury is an independent predictor of adverse outcomes in COVID-19.

Purpose of the Study:

  • To review the prevalence of acute cardiac injury in COVID-19.
  • To explore the underlying mechanisms of SARS-CoV-2-related myocardial injury.
  • To emphasize the clinical significance of cardiac complications during the pandemic.

Main Methods:

  • Literature review of studies on COVID-19 and cardiac injury.
  • Analysis of reported cardiovascular complications in SARS-CoV-2 infected patients.
  • Investigation of potential mechanisms involving ACE2 receptors and related pathways.

Main Results:

  • Cardiovascular complications are frequently observed in COVID-19 patients.
  • The angiotensin-converting enzyme-2 (ACE2) receptor pathway is implicated in myocardial injury.
  • Mechanisms of cardiac injury in SARS-CoV-2 infection require further elucidation.

Conclusions:

  • Acute cardiac injury is a significant concern in COVID-19.
  • Understanding the mechanisms is crucial for patient management.
  • Routine cardiac function assessment is recommended for COVID-19 patients.
Abstract

Keywords:
2019-nCoVAngiotensin-converting enzyme-2COVID-19Cardiac injurySARS‐CoV‐2

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