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Updated: Dec 21, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Lacune is the stroke subtype linked to obstructive sleep apnea
Fawaz Al-Hussain1, Yousef Mohammad2
1Department of Internal Medicine; College of Medicine, King Saud University, P.O. Box 7805, Riyadh, 11472, Kingdom of Saudi Arabia. faalhussain@ksu.edu.sa.
Obstructive sleep apnea is common in ischemic stroke patients. Small artery disease is the most frequent stroke subtype linked to obstructive sleep apnea, requiring vigilant clinical assessment.
Area of Science:
- Neurology
- Sleep Medicine
- Cardiovascular Disease
Background:
- Stroke prevention relies on managing subtype-specific risk factors.
- Obstructive sleep apnea (OSA) is a known risk factor for stroke.
- Limited data exists on the specific stroke subtypes associated with OSA.
Purpose of the Study:
- To investigate the association between obstructive sleep apnea and specific ischemic stroke subtypes.
- To determine the prevalence of OSA in patients admitted with acute ischemic stroke.
Main Methods:
- A single-center observational case series of 170 acute ischemic stroke patients.
- Stroke subtypes were classified using TOAST criteria.
- Obstructive sleep apnea was assessed using the Berlin questionnaire.
Main Results:
- 51% of ischemic stroke patients had obstructive sleep apnea.
- Small artery disease was significantly more prevalent in patients with OSA (44% vs. 26%).
- Hypertension was independently associated with small artery disease in multivariate analysis.
Conclusions:
- Small artery disease is the predominant stroke subtype associated with obstructive sleep apnea.
- Clinicians should actively screen ischemic stroke patients for OSA, particularly those with small artery disease.
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