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Atypical extraventricular neurocytoma: A case report
Peng Zhang1, Cui-Ying Wu1, Jia-Zhen Qin1
1Department of Neurosurgery, the Seventh Medical Center of PLA General Hospital, Beijing, China.
Summary
A rare case of atypical extraventricular neurocytoma (EVN) in a young man highlights its aggressive nature and unique pathological features. Early diagnosis and treatment led to a favorable outcome with no observed neurological deficits.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Pathology
Background:
- Atypical extraventricular neurocytoma (EVN) is a rare central nervous system neoplasm.
- EVN is characterized by diffuse tumor cell hyperplasia, increased neovascularization, necrosis, and aggressive features.
- Distinguishing atypical EVN from typical EVN is crucial for treatment and prognosis.
Observation:
- A case report of a 25-year-old male with atypical EVN in the left parietal-occipital region.
- MRI revealed a well-defined globular mass with heterogeneous signals and mild perilesional edema.
- Histopathological examination showed tumor cells with hyperchromatic nuclei, perinuclear halos, and increased microvascular proliferation within the white matter.
Findings:
- Surgical excision followed by radiotherapy was performed.
- The patient showed no neurological deficits over a 26-month follow-up period.
- Post-treatment MRI indicated a stable tumor bed with slight peritumoral edema.
Implications:
- Atypical EVN presents unique radiographic and pathological characteristics.
- This rare neoplasm exhibits more aggressive properties compared to typical EVN.
- Clinical, histopathological, and immunohistochemical findings are essential for accurate diagnosis and management of atypical EVN.
