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Elevated cardio-ankle vascular index may be related to future stroke risk in Japanese subjects

Yasuhiro Nishiyama1, Toshiaki Otsuka2, Kanako Muraga1

  • 1Department of Neurology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.

Journal of the Neurological Sciences
|May 17, 2020
PubMed

Insights

Cardio-ankle vascular index (CAVI) is linked to higher stroke risk in Japanese adults. Elevated CAVI values may help identify individuals at increased risk for a first-ever stroke.

Area of Science:

  • Vascular health assessment
  • Cardiovascular disease risk stratification

Background:

  • The cardio-ankle vascular index (CAVI) is a proposed marker for arteriosclerotic diseases.
  • Its association with stroke risk in Japanese populations requires clarification.

Purpose of the Study:

  • To investigate the relationship between CAVI and predicted stroke risk in Japanese subjects.
  • To determine if CAVI can serve as a surrogate marker for stroke risk.

Main Methods:

  • A cohort of 280 Japanese adults underwent medical check-ups.
  • CAVI values and arterial dysfunction risk factors were assessed.
  • Predicted 10-year stroke risk was calculated using the Japan Public Health Center study criteria.

Main Results:

  • Age, sex, BMI, and systolic blood pressure independently predicted CAVI.
  • CAVI values were significantly higher in individuals with high predicted stroke risk.
  • The highest CAVI quartile showed a 14.67-fold increased odds of high stroke risk (adjusted).
  • Each quartile increase in CAVI correlated with significantly higher odds of very high predicted stroke risk.

Conclusions:

  • Elevated CAVI values are associated with increased predicted stroke risk.
  • CAVI may be a valuable surrogate marker for identifying individuals at higher risk of first-ever stroke.
Abstract

Keywords:
Cardio-ankle vascular indexCross-sectional studyJapanese middle-aged populationRisk factorsStroke

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