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Updated: Dec 21, 2025

Simultaneous Electrophysiological Recording and Calcium Imaging of Suprachiasmatic Nucleus Neurons
Published on: December 8, 2013
Mechanisms that communicate features of neuronal activity to the genome
Daniel A Heinz1, Brenda L Bloodgood2
1Biological Sciences Graduate Program, University of California, San Diego, La Jolla, CA, 92093, United States.
Abstract:
Stimulus-driven gene expression is a ubiquitous feature of biological systems, allowing cells and organisms to adapt their function in a stimulus-driven manner. Neurons exhibit complex and heterogeneous activity-dependent gene expression, but many of the canonical mechanisms that transduce electrical activity into gene regulation are promiscuous and convergent. We discuss literature that describes mechanisms that drive activity-dependent gene expression with a focus on those that allow the nucleus to decode complex stimulus-features into appropriate transcriptional programs.
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