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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

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Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
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Double security drug delivery system DDS constructed by multi-responsive (pH/redox/US) microgel.

Bin Lei1, Miaoxin Chen1, Yizhou Wang1

  • 1Shanghai Engineering Research Center of Hierarchical Nanomaterials and School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, PR China.

Colloids and Surfaces. B, Biointerfaces
|May 17, 2020
PubMed
Summary

This study developed a novel double-locked drug delivery system using multi-responsive microgels. These microgels ensure targeted release of anticancer drugs like doxorubicin (DOX) triggered by specific pH, redox, and ultrasound stimuli, minimizing side effects.

Keywords:
CopolymersDouble securityDrug delivery systemMulti-responsive microgelsUltrasound

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Drug Delivery Systems

Background:

  • Developing advanced drug delivery systems is crucial for targeted cancer therapy.
  • Existing systems often face challenges with premature drug release and low efficacy.
  • Multi-responsive materials offer potential for enhanced control over drug release kinetics.

Purpose of the Study:

  • To engineer multi-responsive core-shell microgels for a double-locked drug delivery system.
  • To achieve controlled release of anticancer drugs triggered by specific internal and external stimuli.
  • To enhance drug delivery efficiency and reduce side effects.

Main Methods:

  • Synthesis of pH-sensitive poly(2-(diisopropylamino ethylmethacrylate)-block-poly(ethyleneimine)) diblock copolymers (PDPA-b-PEI).
  • Formation of redox-responsive shells using disulfide cross-linkers cleaved by glutathione (GSH).
  • Encapsulation of doxorubicin (DOX) and perfluorohexane (PFH) within the microgel core.
  • Stimulation of drug release using pH, GSH, and ultrasound.

Main Results:

  • Microgels demonstrated pH and redox sensitivity, enabling controlled drug release.
  • DOX release was sustained under specific pH/GSH conditions and abrupt upon ultrasound exposure.
  • Ultrasound stimulus induced complete drug release without destroying microgel structure, showing expansion-recovery.
  • The system exhibited a 'double security' effect, preventing leakage during circulation and ensuring targeted release.

Conclusions:

  • The developed multi-responsive microgels provide a highly controllable and efficient drug delivery platform.
  • Combining endogenous (pH, GSH) and exogenous (ultrasound) stimuli offers precise spatiotemporal drug release.
  • This system promises reduced side effects and improved therapeutic outcomes in cancer treatment.