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Updated: Dec 21, 2025

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A core outcome set for pre-eclampsia research: an international consensus development study.

Jmn Duffy1,2, A E Cairns2, D Richards-Doran2

  • 1Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

BJOG : an International Journal of Obstetrics and Gynaecology
|May 17, 2020
PubMed
Summary
This summary is machine-generated.

A global consensus developed a core outcome set for pre-eclampsia, including 14 maternal and 8 offspring outcomes. This standardized set will improve future research and clinical care for pregnant women and their babies.

Keywords:
Consensus development studycore outcome setmodified Delphi methodmodified nominal group techniqueoutcome reporting biaspre-eclampsia

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Area of Science:

  • Obstetrics and Gynecology
  • Perinatology
  • Clinical Trial Methodology

Background:

  • Pre-eclampsia is a leading cause of maternal and infant mortality worldwide.
  • Existing research on pre-eclampsia often lacks standardized outcome measures, hindering comparability and synthesis.
  • A consensus-driven core outcome set is crucial for improving the quality and relevance of pre-eclampsia research.

Framework:

  • A modified Delphi method and Nominal Group Technique were employed for consensus development.
  • International participation included 281 healthcare professionals, 41 researchers, and 110 patients from 56 countries.
  • A comprehensive list of 116 potential outcomes was refined to a final set of 22 core outcomes.

Implementation:

  • The developed core outcome set comprises 14 maternal and 8 offspring outcomes.
  • Maternal outcomes include death, eclampsia, stroke, and postpartum hemorrhage.
  • Offspring outcomes encompass stillbirth, neonatal mortality, and gestational age at delivery.

Implications:

  • The core outcome set will standardize outcome reporting in future pre-eclampsia randomized trials and systematic reviews.
  • Implementation will enhance the reach and relevance of research findings for clinical practice.
  • This initiative aims to improve the care and outcomes for pregnant women and their newborns affected by pre-eclampsia.