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Direct extracellular electrical stimulation influences density dependent aggregation of fetal rat cerebrocortical
F S Kaplan1, T G Maguire, V M Lee
1McKay Laboratory of Orthopaedic Surgery Research, University of Pennsylvania, School of Medicine, Philadelphia 19104.
Neuroscience Letters
|November 22, 1988
Abstract:
Cells isolated from fetal (E17) rat cerebral cortex form aggregates in a density-dependent manner. Direct current electrical stimulation influences the formation of neuronal aggregates by promoting neuronal survival at a calculated current density of 15 nA/cm2 (with an average calculated field strength of 1 microV/cm), and inhibiting neuronal survival at calculated current densities of both 1 nA/cm2 and 150 nA/cm2. Electrical stimulation had no observable effect on neuronal aggregation independent of its effect on cell survival.