Related Experiment Video

Updated: Dec 21, 2025

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
12:26

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

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Atypical cyclins in cancer: New kids on the block?

Eva Quandt1, Mariana P C Ribeiro1, Josep Clotet1

  • 1Faculty of Medicine and Health Sciences, Universitat Internacional De Catalunya, 08195, Sant Cugat Del Vallès, Barcelona, Spain.

Seminars in Cell & Developmental Biology
|May 18, 2020
PubMed

Insights

Atypical cyclins, though poorly understood, are linked to cancer progression. Research suggests these proteins could serve as new cancer prognostic markers and therapeutic targets.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Atypical cyclins represent a newly identified subfamily of cyclins.
  • They share structural and interaction similarities with canonical cyclins involved in cell cycle regulation and cancer.
  • Their specific roles in cancer pathogenesis remain largely uncharacterized.

Purpose of the Study:

  • To investigate the potential involvement of atypical cyclins in cancer.
  • To explore atypical cyclins as prognostic markers and drug targets in oncology.

Main Methods:

  • Gene expression analysis
  • Prognostic significance assessment
  • Bibliographic data mining

Main Results:

  • Atypical cyclins appear to play roles in processes crucial for sustaining cancer growth.
  • Evidence suggests their potential utility as prognostic indicators in cancer patients.
  • These findings highlight atypical cyclins as possible novel therapeutic targets.

Conclusions:

  • Atypical cyclins are likely implicated in cancer pathogenesis.
  • Further research into atypical cyclins may yield new diagnostic and therapeutic strategies for cancer treatment.
Keywords:
Atypical cyclinsCancerPrognosticTargets

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