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Incidence and risk factors of vascular dementia in Thai stroke patients

Pornpatr A Dharmasaroja1, Chanin Limwongse2, Thammanard Charernboon3

  • 1Department of Medicine, Faculty of Medicine, Thammasat University, Klong 1, Klong Luang, Pathumthani 12120, Thailand; Faculty of Medicine, Chulabhorn International College of Medicine, Thammasat University, Klong 1, Klong Luang, Pathumthani 12120, Thailand.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|May 18, 2020
PubMed

Insights

Vascular dementia (VAD) affects 27% of stroke survivors. Key risk factors include older age, lower education, prior stroke history, and white matter lesions, highlighting the need for targeted VAD prevention strategies.

Area of Science:

  • Neurology
  • Geriatrics
  • Public Health

Background:

  • Vascular cognitive impairment (VCI) significantly impacts stroke survivors' independence.
  • VCI encompasses conditions like vascular mild cognitive impairment (VMCI) and vascular dementia (VAD).

Purpose of the Study:

  • To determine the incidence of vascular dementia (VAD) in Thai stroke patients.
  • To identify risk factors associated with VAD development in this population.

Main Methods:

  • Prospective study of adult ischemic stroke patients.
  • Cognitive function assessed using the Montreal Cognitive Assessment (MOCA)-Thai version (cutoff 24/25) 3-6 months post-stroke.
  • Comparison of demographic, Apolipoprotein E (ApoE) status, and stroke characteristics between VAD and non-VAD groups.

Main Results:

  • VAD diagnosed in 27% (49/180) of patients; 50% had VMCI.
  • Older age (OR 4.99), lower education (OR 10.31), prior stroke (OR 4.96), and moderate-to-severe white matter lesions (OR 5.56) were significant risk factors for VAD.
  • ApoE 4 allele presence did not correlate with increased VAD risk.

Conclusions:

  • Vascular dementia (VAD) is prevalent in 27% of Thai stroke survivors.
  • Older age, limited education, stroke history, and cerebral white matter lesions are key risk factors for VAD.
  • Further research may explore targeted interventions for VAD prevention in stroke populations.
Abstract

Keywords:
Apolipoprotein EAsianStrokeVascular dementia

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