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Related Concept Videos

Characteristics and Nomenclature of Copolymers01:24

Characteristics and Nomenclature of Copolymers

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Copolymers are the products obtained from the polymerization of multiple monomer species. So, in a polymer chain itself, there can be multiple repeating units that come from different monomers. The process of synthesizing a polymer from different monomer species is called copolymerization. When two monomers are involved, the polymer is known as a bipolymer. Polymers with three and four monomers are termed terpolymers and quaterpolymers, respectively. Figure 1 depicts the copolymerization of...
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Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
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Poloxamer: A versatile tri-block copolymer for biomedical applications.

Payam Zarrintaj1, Joshua D Ramsey1, Ali Samadi2

  • 1Chemical Engineering, Oklahoma State University, 420 Engineering North, Stillwater, OK 74078, United States.

Acta Biomaterialia
|May 18, 2020
PubMed
Summary

Poloxamers (Pluronics) are versatile synthetic copolymers with tunable properties for advanced biomedical uses. This review highlights their applications in tissue engineering, drug delivery, and 3D bioprinting.

Keywords:
BiomaterialsBiomedical engineeringDrug deliveryPluronicPoloxamerTissue engineering

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Polymer Chemistry

Background:

  • Poloxamers are synthetic tri-block copolymers with poly(propylene oxide) and poly(ethylene oxide) chains.
  • Their unique temperature-dependent self-assembly and thermo-reversible properties, coupled with biocompatibility, make them ideal for biomedical applications.
  • These properties allow for tailoring microstructure, bioactivity, and mechanical characteristics to mimic native tissues.

Purpose of the Study:

  • To systematically review recent advances in the design and application of poloxamer-based biomaterials.
  • To critically discuss the role of poloxamers in tissue engineering, drug/gene delivery, theranostic devices, and 3D bioprinting.
  • To highlight the expanding potential of poloxamers beyond traditional treatments into novel biomedical frontiers.

Main Methods:

  • Comprehensive literature review of recent research on poloxamer-based biomaterials.
  • Analysis of poloxamer design strategies for specific biomedical applications.
  • Evaluation of poloxamer performance in tissue engineering, drug delivery, and 3D printing contexts.

Main Results:

  • Poloxamers demonstrate significant potential as drug carriers, enhancing drug availability and cancer cell vulnerability.
  • They are effective in modifying hydrophobic tissue-engineered constructs.
  • Recent advances show promise in theranostic devices and bioinks for 3D printing.

Conclusions:

  • Poloxamer-based biomaterials offer a tunable platform for diverse biomedical applications, including advanced tissue engineering and drug delivery systems.
  • Their amphiphilic nature and self-assembly into micelles are key to their efficacy as drug carriers.
  • This review provides a critical discussion of poloxamers' expanding role, marking a new era in biomaterial development.