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An objective method to identify non-responders in neurovascular coupling testing.

Lucy C Beishon1, Claire Al Williams1, Kannakorn Intharakham1

  • 1University of Leicester, Department of Cardiovascular Sciences, Leicester, UK.

Journal of Neuroscience Methods
|May 18, 2020
PubMed
Summary

This study introduces objective criteria to identify non-responders in neurovascular coupling (NVC) research using transcranial Doppler (TCD). The new method helps differentiate individuals who consistently respond to cognitive tasks from those who do not.

Keywords:
Cross-correlation function peakModellingTask-activationTranscranial doppler ultrasonographyVariance ratio

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Physiology

Background:

  • Neurovascular coupling (NVC) assessment via transcranial Doppler (TCD) measures cerebral blood flow velocity (CBFv) during task activation.
  • Individual responses to NVC tasks can be inconsistent, posing challenges for data interpretation.
  • Existing methods lack objective criteria for identifying non-responders in NVC studies.

Purpose of the Study:

  • To develop a robust and objective method for identifying non-responders to task-activation in NVC studies.
  • Establish objective criteria to differentiate between responders and non-responders.
  • Enhance the reliability of NVC research by standardizing response classification.

Main Methods:

  • Utilized resting CBFv data from 135 healthy participants to establish normal variation thresholds.
  • Calculated cross-correlation function peak (CCF) and variance ratio (VR) from bilateral CBFv.
  • Defined responder criteria using the 90th percentile of non-stimulated data (CCF ≥ 0.53 or VR ≥ 2.59) and applied them to task-activated data from 69 participants.

Main Results:

  • Established objective criteria for classifying responders: CCF ≥ 0.53 or VR ≥ 2.59.
  • Applied criteria to five cognitive tasks (attention, verbal fluency, language, visuospatial, memory).
  • Responder rates varied by task, ranging from 58-68% for memory tasks to 78-86% for attention tasks.

Conclusions:

  • Successfully developed and validated objective criteria for differentiating NVC task responders from non-responders.
  • This method provides a standardized approach to classifying participants in NVC studies.
  • A significant proportion of individuals did not meet responder criteria across various cognitive tasks, highlighting the need for objective classification.