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Irritability in Huntington's Disease.

Nicholas E Karagas1, Natalia Pessoa Rocha2,3, Erin Furr Stimming3

  • 1McGovern Medical School at The University of Texas Health Sciences Center (UTHealth), Houston, TX, USA.

Journal of Huntington'S Disease
|May 18, 2020
PubMed
Summary
This summary is machine-generated.

Irritability is a significant neuropsychiatric symptom in Huntington's disease (HD) that current treatments do not fully address. Evaluating existing medications for similar symptoms is a key strategy for better Huntington's disease management.

Keywords:
Huntington’s diseasebehavioral symptomsirritable moodneuropsychiatrypsychotropic drugs

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Huntington's disease (HD) is an inherited neurodegenerative disorder.
  • Irritability, manifesting as anger outbursts, is a common and debilitating neuropsychiatric symptom in HD.
  • This symptom negatively impacts employment and social support systems for HD patients.

Purpose of the Study:

  • To review irritability in the context of Huntington's disease.
  • To highlight the need for improved, tailored treatments for HD-related irritability.
  • To propose evaluating existing medications for similar neuropsychiatric symptoms as a therapeutic strategy.

Main Methods:

  • Review of current literature on Huntington's disease and irritability.
  • Analysis of diagnostic approaches for HD-related irritability.
  • Discussion of current pharmacological interventions (antidepressants, antipsychotics).

Main Results:

  • Irritability is a complex symptom in HD, challenging to measure and manage effectively.
  • Current psychotropic medications offer partial relief but are often insufficient for HD irritability.
  • There is a clear need for more targeted and effective therapeutic options.

Conclusions:

  • Existing treatments for Huntington's disease irritability are often inadequate.
  • Further research is needed to develop better-tailored interventions.
  • Repurposing approved medications for similar neuropsychiatric symptoms presents a promising avenue for managing HD irritability.