Related Experiment Video
Updated: Dec 21, 2025
A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG
Published on: March 7, 2017
Decreased natural killer cells in diffuse intrinsic pontine glioma patients
Lei Zhang1,2,3, Hongwei Yu1, Yixue Xue4
1Department of Neurosurgery, Shengjing Hospital of China Medical University, # 36 Heping District, Shenyang City, 110004, Liaoning Province, China.
Purpose:
Diffuse intrinsic pontine glioma (DIPG) remains the leading cause of death among pediatric brain tumor patients. Its pontine location and aggressive nature make developing effective treatment an ongoing challenge in pediatric oncology. Although studies have found that one of the hallmark features of glioma is immunosuppression, the immune status of DIPG patient is not clearly understood.
Methods:
We tested the lymphocyte profile in four radiologically diagnosed DIPG patients. All the four patients did not receive any steroids, radiotherapy, and chemotherapy before the collection of blood.
Results:
We found decreased natural killer (NK) cell level and increased B cell level in all four cases.
Conclusion:
These findings suggested that decreased NK cells and increased B cells may aid the tumorigenesis and growth seen in DIPG patient. Increased NK and decreased B cells may be the future direction for the treatment of DIPG patient.
