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An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay
Published on: January 26, 2019
Costs of Respiratory Syncytial Virus Hospitalizations in Colombia
Jefferson Antonio Buendía1, Diana Guerrero Patiño2
1Department of Pharmacology and Toxicology, Research Group in Pharmacology and Toxicology (INFARTO), Centro de Información y Estudio de Medicamentos y Tóxicos (CIEMTO), Faculty of Medicine, Universidad de Antioquia, Carrera 51D #62-29, Medellín, Colombia. jefferson.buendia@gmail.com.
Insights
Respiratory syncytial virus (RSV) hospitalizations in Colombian infants incur substantial medical costs, largely due to inappropriate medication use. This highlights the economic burden and need for better prevention strategies.
Area of Science:
- Pediatrics
- Infectious Diseases
- Health Economics
Background:
- Clinical guidelines for respiratory syncytial virus (RSV) management exist, yet medication and test overuse with limited evidence persists.
- RSV infection poses a significant challenge in pediatric healthcare settings.
Purpose of the Study:
- To evaluate the medical costs associated with bronchiolitis hospitalizations caused by RSV in infants under two years old in Colombia.
- To understand the economic impact of RSV on the Colombian healthcare system.
Main Methods:
- A prevalence-based cost-of-illness study was conducted from a societal perspective (2016-2017).
- Cases were defined as laboratory-confirmed RSV infections requiring hospitalization.
- Data on costs and resource utilization were collected directly from medical invoices and health records.
Main Results:
- The study included 193 pediatric patients diagnosed with RSV.
- Average hospital stay was 5.55 days, with room costs (31.5%), drugs (21.8%), and indirect costs (14.9%) being major cost drivers.
- A high percentage of medications, including systemic antibiotics (96%), bronchodilators (90%), and corticosteroids (86%), were deemed inappropriate.
Conclusions:
- RSV infection imposes a significant economic burden on the Colombian health system.
- Comprehensive data on healthcare resource use and costs are crucial for developing cost-effectiveness models.
- Findings can guide the development of targeted RSV prevention strategies.
Background:
Several clinical practice guidelines exist for the management of respiratory syncytial virus (RSV) infection, but the use and overuse of medications and medical tests with insufficient evidence of effectiveness remains substantial.
Objective:
This study aimed to evaluate the medical costs associated with bronchiolitis hospitalizations caused by RSV infection among infants aged < 2 years in Colombia.
Methods:
This was a prevalence-based cost-of-illness multicentric study performed from the societal perspective during 2016-2017. A case was defined as a laboratory-confirmed RSV infection with hospitalization. All costs and use of resources were collected directly from medical invoices and health records.
Results:
This study included 193 patients with a diagnosis of RSV. The average hospital stay duration was 5.55 days. The major contributors to hospitalization costs were room costs (31.5%), drugs (21.8%), and indirect costs (14.9%). Medications with the highest costs were nebulization with a hypertonic solution and systemic antibiotics. In total, 96% of β-lactam antibiotics, 90% of bronchodilators, and 86% of corticosteroids and epinephrine were classified as inappropriate.
Conclusion:
RSV infection in Colombia places a high economic burden on the health system. Generating comprehensive data on healthcare resource use and costs associated with RSV will help to provide valuable information for the development of cost-effectiveness models and to guide RSV-prevention strategies.
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