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Metabolic bone markers can be related to preserved insulin secretion in children with newly diagnosed type 1 diabetes

Małgorzata Szymańska1, Izabela Michałus2, Marcin Kaszkowiak3

  • 1Department of Paediatrics, Oncology, and Haematology, Medical University of Lodz, Poland.

Pediatric Endocrinology, Diabetes, and Metabolism
|May 19, 2020
PubMed

Insights

Type 1 diabetes (T1D) in children is linked to bone metabolism changes, with markers improving as metabolic control is achieved. Preserved insulin secretion appears most crucial in managing these bone complications.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Bone Disease
  • Diabetes Mellitus

Background:

  • Type 1 diabetes (T1D) is associated with bone metabolism disorders.
  • Evaluating bone metabolism markers in children with newly diagnosed T1D is crucial for understanding disease progression and complications.

Purpose of the Study:

  • To assess bone metabolism markers in children with newly diagnosed T1D.
  • To track changes in these markers after an average of seven months of diabetes duration.
  • To correlate bone metabolism markers with clinical parameters of diabetes.

Main Methods:

  • Evaluated osteocalcin (OC), osteoprotegerin (OPG), sRANKL, and deoxypyridoline (DPD) in 100 T1D patients and 52 controls.
  • Performed DXA examinations for bone mineral density.
  • Assessed markers at diagnosis and during follow-up.

Main Results:

  • Lower OC and higher OPG at T1D onset compared to controls; OC increased, OPG decreased during follow-up.
  • sRANKL and urine DPD increased during follow-up and were higher than controls.
  • BMD-TBLH was lower in T1D patients than controls.
  • OPG correlated with HbA1c, C-peptide, and BMI Z-score; sRANKL correlated with C-peptide levels.

Conclusions:

  • Bone metabolism disorders in children with T1D are evident at diagnosis and modify with metabolic control.
  • These bone changes are strongly associated with preserved insulin secretion.
Abstract

Keywords:
densitometryosteocalcinosteoprotegerins-RANKLtype 1 diabetes

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