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Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
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Nucleos(t)ide analogues and Hepatitis B virus-related hepatocellular carcinoma: A literature review

Mohamed A Abd El Aziz1, Rodolfo Sacco2, Antonio Facciorusso2

  • 1Department of Surgery, Mayo Clinic, Rochester, MN, USA.

Antiviral Chemistry & Chemotherapy
|May 19, 2020
PubMed

Insights

Nucleos(t)ide analogues effectively treat Hepatitis B virus, reducing hepatocellular carcinoma incidence. This review examines these treatments and their impact on liver cancer management before, during, and after therapies.

Area of Science:

  • Hepatology
  • Oncology
  • Virology

Background:

  • Hepatitis B virus (HBV) is a primary cause of hepatocellular carcinoma (HCC), the fourth leading cause of cancer mortality globally.
  • Effective antiviral therapy is crucial for managing HBV infection and preventing HCC progression.

Purpose of the Study:

  • To review nucleos(t)ide analogues (NAs) used for Hepatitis B virus treatment.
  • To analyze the relationship between NA treatment and hepatocellular carcinoma development.
  • To evaluate the impact of NA therapy timing on HCC treatment outcomes.

Main Methods:

  • Literature review of studies on nucleos(t)ide analogues for HBV treatment.
  • Analysis of data correlating NA therapy with HCC incidence and progression.
  • Examination of studies investigating NA use in conjunction with HCC therapies.

Main Results:

  • Nucleos(t)ide analogue treatment significantly decreases HBV replication and lowers the risk of HCC.
  • Different classes of NAs exhibit varying efficacy and safety profiles.
  • Optimal timing of NA therapy in relation to HCC interventions like surgery, chemoembolization, and chemotherapy is critical for patient outcomes.

Conclusions:

  • Nucleos(t)ide analogues are essential in managing chronic Hepatitis B virus infection and preventing hepatocellular carcinoma.
  • Understanding the nuances of NA therapy, including timing around HCC treatments, can improve patient survival and disease management.
Keywords:
Hepatitis B virusHepatocellular carcinomaadefovirentecavirlamivudinenucleos(t)ide analoguestelbivudine interferontenofovir

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