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Synthesis of New Piperazine Substituted Chalcone Sulphonamides as Antibacterial Agents
Yan-Ling Tang1, Yong-Kun Li1, Min-Xin Li1
1College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, China.
Background:
Infection is a global threat to human health, and there is an urgent need to develop new effective antibacterial drugs to treat bacterial infections.
Objective:
To study the antibacterial activity of piperazine substituted chalcone sulphonamides.
Materials And Methods:
A series of novel piperazine substituted chalcone sulphonamides have been prepared, and in vitro antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli strains were evaluated.
Results:
The results showed that derivatives 6a, 6c and 6h displayed good antibacterial activity against Bacillus subtilis with MIC values of 4.0-8.0 mg/mL.
Conclusion:
Piperazine substituted chalcone sulphonamides may be used as potential antibacterial agents.
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