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Updated: Dec 21, 2025

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
Published on: June 26, 2018
Autoantibodies against cytokines: phenocopies of primary immunodeficiencies?
Chen-Lung Ku1,2, Chih-Yu Chi3,4, Horst von Bernuth5,6,7
1Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan City, Taiwan. clku@cgu.edu.tw.
Abstract:
Anti-cytokine autoantibodies may cause immunodeficiency and have been recently recognized as 'autoimmune phenocopies of primary immunodeficiencies' and are found in particular, but not exclusively in adult patients. By blocking the cytokine's biological function, patients with anti-cytokine autoantibodies may present with a similar clinical phenotype as the related inborn genetic disorders. So far, autoantibodies to interferon (IFN)-γ, GM-CSF, to a group of TH-17 cytokines and to IL-6 have been found to be causative or closely associated with susceptibility to infection. This review compares infectious diseases associated with anti-cytokine autoantibodies with primary immunodeficiencies affecting similar cytokines or related pathways.
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