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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
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MUCO-DIS: a New AFM-Based Nanoscale Dissolution Technique.

Muhammad Usman Ghori1, Jorabar Singh Nirwan2, Taimoor Asim3

  • 1Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield, HD1 3DH, UK. m.ghori@hud.ac.uk.

AAPS Pharmscitech
|May 19, 2020
PubMed
Summary

A new AFM-based muco-dissolution technique simultaneously assesses mucoadhesion, topography, and drug release. This method offers a standardized approach for evaluating mucoadhesive drug delivery systems across various mucosal surfaces.

Keywords:
3D printingAFMEx vivoadhesion forcedrug releasegastrointestinal mucosamatrix erosionmucoadhesionnanodissolutionnanoscalesurface roughnesssurface texture

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Biotechnology

Background:

  • Mucoadhesion-based drug delivery systems enhance drug residence time and prolong action.
  • Current mucoadhesion testing lacks standardization and struggles to correlate multiple parameters like surface interaction, topography, and drug release.
  • Separate testing methods lead to subjective and difficult-to-correlate results.

Purpose of the Study:

  • To develop a novel Atomic Force Microscopy (AFM)-based single-entity ex vivo muco-dissolution (MUCO-DIS) technique.
  • To simultaneously evaluate mucoadhesion force, 3D surface topography, polymer dissolution, and drug release characteristics.
  • To demonstrate the technique's utility by studying pectin microparticle interactions with various gastrointestinal mucosal surfaces.

Main Methods:

  • Development of a new AFM-based MUCO-DIS technique.
  • Simultaneous measurement of mucoadhesion force, 3D surface topography, polymer dissolution, and drug release.
  • Ex vivo testing of model pectin microparticles containing metformin HCl on gastric, small intestine, large intestine, and buccal mucosal surfaces.

Main Results:

  • The MUCO-DIS technique successfully determined mucoadhesion force, polymer dissolution, and drug release.
  • The study revealed differences in microparticle performance across various mucosal targets.
  • The technique provided nanoscale insights into material-substrate interactions in a hydrated state.

Conclusions:

  • The developed MUCO-DIS technique is a valuable tool for characterizing mucoadhesive pharmaceutical formulations.
  • This novel system enables simultaneous evaluation of critical parameters, overcoming limitations of separate testing methods.
  • The technique has potential applications beyond pharmaceuticals for evaluating material interactions in hydrated states.